Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent

J Med Chem. 1996 Mar 15;39(6):1193-5. doi: 10.1021/jm960012o.

Authors

S A Munk¹, R K Lai, J E Burke, P N Arasasingham, A B Kharlamb, C A Manlapaz, E U Padillo, M K Wijono, D W Hasson, L A Wheeler, M E Garst

Affiliation

¹ Allergan Pharmaceuticals, Irvine, California, 92715, USA.

PMID: 8632424
DOI: 10.1021/jm960012o

No abstract available

MeSH terms

Adrenergic alpha-Agonists / chemical synthesis*
Adrenergic alpha-Agonists / metabolism
Adrenergic alpha-Agonists / pharmacology
Animals
Binding Sites
Blood Pressure / drug effects
Bridged Bicyclo Compounds / chemical synthesis*
Bridged Bicyclo Compounds / metabolism
Bridged Bicyclo Compounds / pharmacology
CHO Cells
Cricetinae
Heptanes / chemical synthesis*
Heptanes / metabolism
Heptanes / pharmacology
Humans
Imidazoline Receptors
Macaca fascicularis
Rats
Receptors, Drug / metabolism*

Substances

AGN 192403
Adrenergic alpha-Agonists
Bridged Bicyclo Compounds
Heptanes
Imidazoline Receptors
Receptors, Drug